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World J Hepatol. Apr 27, 2022; 14(4): 647-669
Published online Apr 27, 2022. doi: 10.4254/wjh.v14.i4.647
Revolution in the diagnosis and management of hepatitis C virus infection in current era
Farina M Hanif, Zain Majid, Nasir Hassan Luck, Abbas Ali Tasneem, Syed Muddasir Laeeq, Muhammed Mubarak
Farina M Hanif, Zain Majid, Nasir Hassan Luck, Abbas Ali Tasneem, Syed Muddasir Laeeq, Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation , Karachi 74200, Sindh, Pakistan
Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation , Karachi 74200, Sindh, Pakistan
Author contributions: Farina M Hanif, Zain Majid, Nasir Hassan Luck, Abbas Ali Tasneem, Syed Muddasir Laeeq, Muhammed Mubarak and Luck NL conceived the study; Tasneem AA and Laeeq SM designed the study; Hanif FM and Majid Z performed the research; all authors participated in primary and final drafting; all authors have read and approve the final manuscript; all authors significantly contributed to the study.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammed Mubarak, FCPS, Professor, Department of Histopathology, Sindh Institute of Urology and Transplantation , Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com
Received: August 15, 2021
Peer-review started: August 15, 2021
First decision: December 16, 2021
Revised: February 5, 2022
Accepted: April 2, 2022
Article in press: April 2, 2022
Published online: April 27, 2022
Processing time: 250 Days and 2.5 Hours
Core Tip

Core Tip: Chronic hepatitis C virus (HCV) infection is a major public health threat worldwide, particularly in resource-constrained countries. Although significant advances have been made in the early diagnosis and treatment of the disease, many unmet challenges remain to be tackled, particularly the affordability, equitable distribution and access to these methods. The World Health Organization aims to eliminate viral hepatitis including HCV by 2030. This frontier article addresses the burden of chronic HCV infection, delineates the current therapeutic options, and identifies future strategies to tackle this highly prevalent disease.