Hepatocellular carcinoma: Understanding molecular mechanisms for defining potential clinical modalities

doi:10.4254/wjh.v13.i11.1568

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Nov 27, 2021 (publication date) through Dec 26, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2021; 13(11): 1568-1583
Published online Nov 27, 2021. doi: 10.4254/wjh.v13.i11.1568

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Figure 5 Schematic illustration of epigenetic modifications observed in hepatocellular carcinoma and chromatin modifiers targeted by epi-drugs. The figure represents general epigenetic alterations observed in hepatocellular carcinoma and different epigenetic modifiers that can be targeted via small molecule inhibitors. Moreover, DNA and chromatin mediated alterations observed in tumors are highlighted. Changes in DNA methylation and histone post-translational modifications levels inside normal cells lead to tumor formation. HCC: Hepatocellular carcinoma; HDM: Histone demethylase; HDAC: Histone deacetylase; HMT: Histone methyltransferase; DNMT: DNA methyltransferase; HAT: Histone acetyltransferase.

Citation: Natu A, Singh A, Gupta S. Hepatocellular carcinoma: Understanding molecular mechanisms for defining potential clinical modalities. World J Hepatol 2021; 13(11): 1568-1583
URL: https://www.wjgnet.com/1948-5182/full/v13/i11/1568.htm
DOI: https://dx.doi.org/10.4254/wjh.v13.i11.1568