Hepatitis C eradication with sofosbuvir leads to significant metabolic changes

Figure 1 Effects of hepatitis C eradication on hemoglobin A1C. Vertical axis represents HbA1C levels in mg/dL. HbA1C significantly decreased after eradication of hepatitis C virus (pretreatment 6.66 ± 0.95 mg/dL vs post-treatment 6.14 ± 0.65 mg/dL, P < 0.005). HbA1C: Hemoglobin A1C.

Figure 2 Effects of hepatitis C eradication on lipids. Vertical axis represents lipid levels in mg/dL. LDL and total cholesterol were significantly higher post hepatitis C eradication (LDL: 99.5 ± 28.9 mg/dL vs 128.3 ± 34.9 mg/dL, P < 0.001; total cholesterol 171.6 ± 32.5 mg/dL vs 199.7 ± 40.0 mg/dL, P < 0.001). No significant changes were noted for HDL and triglycerides. LDL: Low-density lipoprotein; HDL: High-density lipoprotein.