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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 18, 2016; 8(35): 1557-1563
Published online Dec 18, 2016. doi: 10.4254/wjh.v8.i35.1557
Published online Dec 18, 2016. doi: 10.4254/wjh.v8.i35.1557
Hepatitis C eradication with sofosbuvir leads to significant metabolic changes
Amilcar L Morales, Hepatology Service, San Antonio Military Medical Center, San Antonio, TX 78234, United States
Amilcar L Morales, Zachary Junga, Maria Sjogren, Dawn Torres, Manish B Singal, Gastroenterology Service, Walter Reed National Military Medical Center, Bethesda, MD 20889, United States
Zachary Junga, Department of Internal Medicine, Walter Reed National Military Medical Center, Bethesda, MD 20889, United States
Author contributions: Morales AL designed the study; Morales AL and Junga Z collected and analyzed the data, and drafted the manuscript; Singla MB performed statistical analysis and manuscript review; Sjogren M and Torres D revised the manuscript for important intellectual content, and help with development of the manuscript and study design; all authors have read and approved the final version to be published.
Institutional review board statement: The study protocol was reviewed and approved by the Walter Reed National Military Medical Center Institutional Review Board.
Informed consent statement: Informed consent was not provided by patients. The Walter Reed National Military Medical Center Institutional Review Board provided a waiver of informed consent authorizing the use of de-identified patient data for research purpose.
Conflict-of-interest statement: No potential conflicts of interest to report.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at amilcar.l.moralescardona.mil@mail.mil.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Amilcar L Morales, MD, Transplant Hepatology Staff, Hepatology Service, San Antonio Military Medical Center, 3551 Roger Brooke Dr, Fort Sam Houston, San Antonio, TX 78234, United States. amcardona2002@yahoo.com
Telephone: +1-210-8729581
Received: August 15, 2016
Peer-review started: August 23, 2016
First decision: September 6, 2016
Revised: September 26, 2016
Accepted: October 22, 2016
Article in press: October 24, 2016
Published online: December 18, 2016
Processing time: 122 Days and 9.2 Hours
Peer-review started: August 23, 2016
First decision: September 6, 2016
Revised: September 26, 2016
Accepted: October 22, 2016
Article in press: October 24, 2016
Published online: December 18, 2016
Processing time: 122 Days and 9.2 Hours
Core Tip
Core tip: In our retrospective study, we evaluated the changes in glucose and lipid metabolism in a group of hepatitis C patients treated and cured with a sofosbuvir-containing regimen. We used hemoglobin A1c (HgA1c) and lipid panels to assess those two parameters. Six months post eradication, we found a statistically significant drop in HgA1c and an increase in low-density lipoprotein and total cholesterol. The use of HgA1c, although not perfect, is easy to understand and is frequently used by primary care doctors as a tool to assess glucose control.