Mallory-Denk body pathogenesis revisited

Figure 1 Mallory-Denk bodie/FAT10 positive hepatocytes were double stained with fluorescent antibodies to FAT10/histone deacetylase 1 and ubiquitin/histone deacetylase 1, showing increased nuclear staining for histone deacetylase 1. A: FAT10 positive hepatocytes (× 436); B: Hepatocytes forming ubiquitin positive Mallory-Denk bodies (× 1090). HDAC-1: histone deacetylase 1; DDC: diethyl-1,4-dihydro-2,4,6-trimethyl-3,5-pyridine decarboxylate.

Figure 2 Diagram of the Toll-like recepter 4 signaling pathway modified from Wikipedia Commons.