Does granulocyte-colony stimulating factor administration induce damage or repair response in schistosomiasis?

Figure 1 Experimental design. w: week; p.i.: post infection.

Figure 2 Effect of treatment on. A: body weight; B: liver weight; C: egg load in intestine; and D: egg load in liver.

Figure 3 Preinfection treated animals sacrificed. A: 10 d post infection (H&E × 200); B: 4 wk post infection (wpi) (Masson trichrome × 200); C,D: 6 wpi (Masson trichrome and H&E × 200). PMN: polymorphonuclear.

Figure 4 Liver sections in Schistosoma mansoni-infected untreated mice. A,B: 10 d post infection (H&E × 200); C: 4 wk post infection (wpi) (H&E × 200); D: 6 wpi (Masson trichrome × 100); E: 8 wpi (Masson trichrome × 100).

Figure 5 Animals treated 3 wk post infection and sacrificed. A: 4 wk post infection (wpi) (H&E × 100); B: 6 wpi (Masson trichrome × 100); C: 8 wpi (Masson trichrome × 100).

Figure 6 Mice treated 5 wk post infection and sacrificed. A: 6 wk post infection (wpi) (Masson trichrome × 200); B: 8 wpi (Masson trichrome × 100).

Figure 7 Mice treated at 7 wk post infection and sacrificed at 8 wk post infection showing multiple variablesized fibrocellular and fibrous lobular granulomas distorting the hepatic lobular architecture (Masson trichrome × 200).

Figure 8 The effect of therapy on granuloma diameter.

Figure 9 Effect of treatment on collagen content.