Successful treatment of acute liver failure due to Wilson’s disease: Serendipity or fortuity?

Figure 1 Diagnostic process, therapeutic interventions, and outcome in a patient with acute liver failure due to Wilson’s disease (Case 1). ALP: Alkaline phosphatase; TB: Total bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; 24 hour-UCE: 24-hour urinary copper excretion; WD: Wilson’s disease; ANA: Anti-nuclear antibody; KF: Kayser-Fleischer; AIH: Autoimmune hepatitis.

Figure 2 Time course of laboratory data and response to treatment in a patient with acute liver failure due to Wilson’s disease (Case 1). This figure shows the temporal trend of laboratory data and treatment from the onset to the last observation. A: Temporal trend of liver enzymes (expressed as UI/L); B: Temporal trend of bilirubin levels (expressed as mg/dL); C: Temporal trend of platelets (expressed as × 10³ /μL); D: Temporal trend of international normalized ratio. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; INR: International normalized ratio.

Figure 3 Diagnostic process, therapeutic interventions, and outcome in a patient with acute liver failure due to Wilson’s disease (Case 2). 24 hour-UCE: 24-hour urinary copper excretion; AIH: Autoimmune hepatitis; ALP: Alkaline phosphatase; ANA: Anti-nuclear antibody; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; KF: Kayser-Fleischer; TB: Total bilirubin; WD: Wilson’s disease.