Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2024; 16(8): 1111-1119
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1111
Successful treatment of acute liver failure due to Wilson’s disease: Serendipity or fortuity?
Valeria Delle Cave, Fabiola Di Dato, Pier Luigi Calvo, Maria Immacolata Spagnuolo, Raffaele Iorio
Valeria Delle Cave, Fabiola Di Dato, Maria Immacolata Spagnuolo, Raffaele Iorio, Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples 80131, Italy
Pier Luigi Calvo, Pediatric Gastroenterology Unit, Regina Margherita Children's Hospital, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, Turin 10126, Italy
Co-first authors: Valeria Delle Cave and Fabiola Di Dato.
Author contributions: Iorio R designed the research study; Iorio R, Delle Cave V, and Di Dato F performed the research and wrote the manuscript; Iorio R, Delle Cave V, Di Dato F, Spagnuolo MI, and Calvo PL reviewed and edited the manuscript for important intellectual content. All authors have read and approved the final manuscript. Delle Cave V and Di Dato F contributed equally to this work as co-first authors.
Institutional review board statement: Consent of the bioethics committee was waived because of the retrospective nature of the study.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All relevant data are within the paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Raffaele Iorio, MD, Associate Professor, Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Via Pansini 5, Naples 80131, Italy. riorio@unina.it
Received: April 27, 2024
Revised: May 28, 2024
Accepted: June 18, 2024
Published online: August 27, 2024
Processing time: 115 Days and 22.5 Hours
Core Tip

Core Tip: There is no firm recommendation on the management of acute liver failure due to Wilson's disease, for which liver transplantation is the only reliable treatment option. The retrospective study highlights the successful treatment of a patient with an unconventional low-dose therapy of D-penicillamine and zinc plus steroids with the aim of opening new perspectives in the management of the condition, stimulating a critical evaluation on the topic and thus promoting the use of all possible therapeutic opportunities to increase survival with the native liver.