Alpha-1 antitrypsin deficiency and Pi*Z allele as important co-factors in the development of liver fibrosis

Figure 1 Receiver operating characteristic curves illustrating the diagnostic ability of the patients’ age, age at diagnosis, and alpha-1 antitrypsin at diagnosis in predicting a nonalcoholic fatty liver disease fibrosis score value that does not exclude advanced fibrosis. A: The patients’ age; B: Age at diagnosis; C: Alpha-1 antitrypsin at diagnosis. AAT: Alpha-1 antitrypsin; AUC: Area under the curve.

Figure 2 Receiver operating characteristic curves illustrating the diagnostic ability of the patients’ age and age at diagnosis in predicting a fibrosis-4 index indicative of moderate to advanced fibrosis. A: The patients’ age; B: Age at diagnosis. AUC: Area under the curve.

Figure 3 Proposed algorithm for the screening of liver disease in patients with alpha-1 antitrypsin deficiency. DM: Diabetes mellitus; AAT: Alpha-1 antitrypsin; FIB-4: Fibrosis-4 index; NFS: Nonalcoholic fatty liver disease fibrosis score; AATD: Alpha-1 antitrypsin deficiency; TE: Transient elastography; LSM: Liver stiffness measurement.