Overexpression of proteasome 26S subunit non-ATPase 6 protein and its clinicopathological significance in intrahepatic cholangiocarcinoma

Figure 1 Growth inhibition of 17 intrahepatic cholangiocarcinoma cell lines after proteasome 26S subunit non-ATPase 6 gene knockout. PSMD6: Proteasome 26S subunit non-ATPase 6.

Figure 2 Expression of proteasome 26S subunit non-ATPase 6 protein in normal intrahepatic bile duct epithelial tissues and intrahepatic cholangiocarcinoma tissues. A: HPA036921 antibody; patient ID: 2429; normal bile duct cells; staining: Negative; intensity: Negative; quantity: 0; B: HPA036922 antibody; patient ID: 3222; normal bile duct cells; staining: Negative; intensity: Negative; quantity: 0. Images represent the tissue at 20 μm magnification; C: HPA036921 antibody; patient ID: 3625; intrahepatic cholangiocarcinoma (ICC) cells; staining: High; intensity: Strong; quantity: > 75%; localization: Cell membrane/cytoplasm; D: HPA036922 antibody; patient ID: 3625; ICC cells; staining: Moderate; intensity: Moderate; quantity: > 75%; localization: Nucleus. Images represent the tissue at 20 μm magnification.

Figure 3 Expression of proteasome 26S subunit non-ATPase 6 protein in adjacent non-tumor tissue of intrahepatic cholangiocarcinoma and intrahepatic cholangiocarcinoma tissue. A: Images are derived from adjacent non-tumor tissue samples of intrahepatic cholangiocarcinoma, representing the tissue at 50 μm magnification; B: Images are derived from intrahepatic cholangiocarcinoma samples, representing the tissue at 50 μm magnification.

Figure 4 High expression of proteasome 26S subunit non-ATPase 6 protein in intrahepatic cholangiocarcinoma. A: Violin plot; B: Receiver operating characteristic curve. PSMD6: Proteasome 26S subunit non-ATPase 6; FPR: False positive rate.