Diagnostic value of tissue plasminogen activator-inhibitor complex in sepsis-induced liver injury: A single-center retrospective case-control study

Figure 1 Patient flow diagram. SILI: Sepsis-induced liver injury; ICU: Intensive care unit.

Figure 2 Investigation of the most valuable variables using random forests analysis. A: Boxplot for all features in random forest analysis. Green indicates important variables; red, blue, or yellow, rejected variables; B: Rejection or acceptance of factors during random forest classification runs. ICU: Intensive care unit; WBC: White blood cell; HGB: Hemoglobin; PIC: α2-plasmin inhibitor-plasmin complex; APTT: Activated partial thrombin time; RBC: Red blood cell; CRP: C-reaction protein; FIB: Fibrinogen; TT: Thrombin time; TM: Thrombomodulin; FDP: Fibrinogen degradation product; TAT: Thrombin-antithrombin complex; PT: Prothrombin time; Cr: Creatinine; Lac: Lactate; t-PAIC: Tissue plasminogen activator-inhibitor complex.

Figure 3 Receiver operating characteristic curve to assess the ability of tissue plasminogen activator-inhibitor complex to diagnose sepsis-induced liver injury. t-PAIC: Tissue plasminogen activator-inhibitor complex; AUC: Area under the receiver operating characteristic curve.

Figure 4 Comparison of patients stratified based on an optimal tissue plasminogen activator-inhibitor complex cutoff of 11. 9 ng/mL. A: Acute Physiology and Chronic Health Evaluation II score; B: Lactate levels; C: Kaplan-Meier survival curves. APACHE II: Acute Physiology and Chronic Health Evaluation II; t-PAIC: Tissue plasminogen activator-inhibitor complex; Lac: Lactate; CI: Confidence interval.

Figure 5 Analysis of correlations of tissue plasminogen activator-inhibitor complex with lactate and aspartate aminotransferase. A: Lactate; B: Aspartate aminotransferase. AST: Aspartate aminotransferase; Lac: Lactate; t-PAIC: Tissue plasminogen activator-inhibitor complex.

Figure 6 Analysis of tissue plasminogen activator-inhibitor complex levels in patients with different Child-Pugh classifications. t-PAIC: Tissue plasminogen activator-inhibitor complex.