Non-invasive tests for predicting liver outcomes in chronic hepatitis C patients: A systematic review and meta-analysis

Figure 1 Flow diagram of search methodology and selection process.

Figure 2 Unadjusted and adjusted hazard ratios of fibrosis-4 index (A), aspartate aminotransferase to platelet ratio score (B), liver stiffness measurement (C), and hepatocellular carcinoma risk. ¹Cirrhosis and direct acting antiviral-treated cohort. ²Cirrhosis and interferon-treated cohort. ³Non-cirrhotic and direct acting antiviral-treated cohort. ⁴Non-cirrhotic and interferon-treated cohort. ⁵Sustained virologic response cohort. ⁶Non-sustained virologic response cohort. DAA: Direct-acting antiviral; FIB-4: Fibrosis-4 index; pegIFN/RBV: Pegylated interferon and ribavirin; SVR: Sustained virologic response.

Figure 3 Forest plots showing hepatocellular carcinoma predictive performance vs random of fibrosis-4 (A), random of aspartate aminotransferase to platelet ratio (B), and random of liver stiffness measurement (C). DAA: Direct-acting antiviral; FIB-4: Fibrosis-4 index; pegIFN/RBV: Pegylated interferon and ribavirin; SVR: Sustained virologic response. APRI: Aspartate aminotransferase to platelet ratio index; LSM: Liver stiffness measurement.

Figure 4 Funnel plots for adjusted hazard ratios of Fibrosis-4 (A), aspartate aminotransferase to platelet ratio (B), and liver stiffness measurement (C) for the evaluation of hepatocellular carcinoma development.