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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2021; 13(8): 949-968
Published online Aug 27, 2021. doi: 10.4254/wjh.v13.i8.949
Published online Aug 27, 2021. doi: 10.4254/wjh.v13.i8.949
Non-invasive tests for predicting liver outcomes in chronic hepatitis C patients: A systematic review and meta-analysis
Tanat Yongpisarn, Chanattha Thimphitthaya, Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Bangkok 10330, Thailand
Passisd Laoveeravat, Division of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington, KY 40536, United States
Nicha Wongjarupong, Department of Internal Medicine, University of Minnesota, Minneapolis, MN 55455, United States
Roongruedee Chaiteerakij, Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand
Roongruedee Chaiteerakij, Center of Excellence for Innovation and Endoscopy in Gastro
Author contributions: Yongpisarn T contributed to acquisition of data, data analysis and interpretation, drafting the article, and final approval; Thimphitthaya C contributed to acquisition of data, analysis and interpretation of data, drafting the article, and final approval; Laoveeravat P contributed to analysis and interpretation of data and final pproval; Wongjarupong N contributed to analysis and interpretation of data and final approval; Chaiteerakij R contributed to study concept, interpretation of data, critical revision, and final approval.
Supported by Research Grant for New Scholar Ratchadaphiseksomphot Endowment Fund Chulalongkorn University , No. RGN_2559_055_10_30 .
Conflict-of-interest statement: The authors deny any conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Roongruedee Chaiteerakij, MD, PhD, Associate Professor, Doctor, Lecturer, Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Patumwan, Bangkok 10330, Thailand.
Received: March 25, 2021
Peer-review started: March 25, 2021
First decision: June 4, 2021
Revised: June 14, 2021
Accepted: July 13, 2021
Article in press: July 13, 2021
Published online: August 27, 2021
Processing time: 148 Days and 3.3 Hours
Peer-review started: March 25, 2021
First decision: June 4, 2021
Revised: June 14, 2021
Accepted: July 13, 2021
Article in press: July 13, 2021
Published online: August 27, 2021
Processing time: 148 Days and 3.3 Hours
Core Tip
Core Tip: Previous meta-analyses have evidenced the potential of non-invasive tests (NITs) in determining prognosis. However, these syntheses included studies on chronic liver diseases from various etiologies and did not comprehensively explore all liver-related outcomes. We aimed to assess the importance of validated NITs in risk stratification, specifically in chronic hepatitis C (CHC) patients. Fibrosis-4 (FIB-4) index, aspartate aminotransferase to platelet ratio (APRI) score and liver stiffness mea