Non-invasive real-time assessment of hepatic macrovesicular steatosis in liver donors: Hypothesis, design and proof-of-concept study

Figure 1 Principle and set-up of the hand-held real time device to measure macrovesicular steatosis. A: Optoelectronics circuit, B: Handheld point of care device.

Figure 2  Proof-of-concept study using the prototype model of the device.

Figure 3 Comparison between large animal liver retrieved from abattoir and 100% fat. A: Absorbance spectrum of abattoir retrieved large animal liver and 100% fat (inset: intensity spectrums of liver and 100% fat); B: Calculated absorbance response of abattoir retrieved large animal liver and 100% fat.

Figure 4 Schematic representation of the proposed study design, experimental setup, and hypothesis towards the development of handheld device. It consists of reflectance probe bundle with home-made plastic block to house light emitting diode, photodetector, optoelectronic circuitry, and display. PD: Photodetector.