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World J Hepatol. Mar 18, 2017; 9(8): 409-417
Published online Mar 18, 2017. doi: 10.4254/wjh.v9.i8.409
Limitations and opportunities of non-invasive liver stiffness measurement in children
Guido Engelmann, Jasmin Quader, Ulrike Teufel, Jens Peter Schenk
Guido Engelmann, Jasmin Quader, Department of Paediatrics, Lukas Hospital, D-41464 Neuss, Germany
Ulrike Teufel, Department of General Paediatrics, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, D-69120 Heidelberg, Germany
Jens Peter Schenk, Department of Diagnostic and Interventional Radiology, Division of Paediatric Radiology, University Hospital of Heidelberg, 69120 Heidelberg, Germany
Author contributions: Engelmann G performed most of the writing of the manuscript; Quader J created the figures and tables and performed the statistical analyses; Teufel U coordinated the writing and performed data analyses; Schenk JP wrote the sections on real-time tissue elastography and magnetic resonance elastography.
Conflict-of-interest statement: There is no conflict of interest associated with any of the authors who contributed their efforts in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Guido Engelmann, MD, Department of Paediatrics, Lukas Hospital, Preussenstraße 84, D-41464 Neuss, Germany. engelmann@lukasneuss.de
Telephone: +49-2131-8883501 Fax: +49-2131-8883599
Received: October 7, 2016
Peer-review started: October 10, 2016
First decision: November 11, 2016
Revised: December 27, 2016
Accepted: January 11, 2017
Article in press: January 14, 2017
Published online: March 18, 2017
Processing time: 156 Days and 21.3 Hours
Core Tip

Core tip: Non-invasive liver stiffness measurement is a new and helpful tool for assessing liver fibroses in children, but it cannot yet replace liver biopsy.