Retrospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 8, 2017; 9(7): 391-400
Published online Mar 8, 2017. doi: 10.4254/wjh.v9.i7.391
Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites
Neeta K Venepalli, Mary V Modayil, Stephanie A Berg, Tad D Nair, Mayur Parepally, Priyanka Rajaram, Ron C Gaba, James T Bui, Yue Huang, Scott J Cotler
Neeta K Venepalli, Tad D Nair, Mayur Parepally, Priyanka Rajaram, Yue Huang, Department of Medicine, Section of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL 60612, United States
Mary V Modayil, Applied Research and Evaluation Services, Department of Evaluation and Analytics, Primary Health Care, Alberta Health Services, Edmonton, Alberta T5K 0L4, Canada
Stephanie A Berg, Department of Medicine, Division Hematology Oncology, Loyola University Medical Center, Maywood, Il, 60153, United States
Ron C Gaba, James T Bui, Department of Radiology, Section of Interventional Radiology, University of Illinois at Chicago, Chicago, IL 60612, United States
Scott J Cotler, Department of Medicine, Division of Hepatology, Loyola University Medical Center, Maywood, IL 60153, United States
Author contributions: Venepalli NK designed and performed the research and wrote the paper; Modayil MV designed the research and contributed to the data analysis; Berg SA, Nair TD, Parepally M, Rajaram P, Gaba RC, Bui JT and Huang Y provided clinical advice and performed the research; Cotler SJ designed and performed the research, provided clinical advice and supervised the report.
Institutional review board statement: This was a retrospective study which was approved by the University of Illinois IRB as an expedited review, under expedited category 5 (Protocol 2005-0283). As such, it was granted a waiver of informed consent and HIPAA authorization.
Informed consent statement: This study was approved under expedited category 5 (Protocol 2005-0283). As such, it was granted a waiver of informed consent and HIPAA authorization.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Neeta K Venepalli, MD, MBA, Assistant Professor of Hematology and Oncology, Department of Medicine, Section of Hematology/Oncology, University of Illinois at Chicago, 840 South Wood Street, 820-E CSB, Chicago, IL 60612, United States. nkv@uic.edu
Telephone: +1-312-9961581 Fax: +1-312-4134131
Received: September 24, 2016
Peer-review started: September 28, 2016
First decision: October 20, 2016
Revised: December 29, 2016
Accepted: January 16, 2017
Article in press: January 18, 2017
Published online: March 8, 2017
Core Tip

Core tip: This is a retrospective study evaluating features of hepatocellular carcinoma (HCC) in Hispanics compared to those of African Americans and Whites. This large single institution study found that Hispanic patients with HCC presented with more modifiable risk factors, more advanced liver disease, and shorter survival compared to African American and White patients with HCC. Early identification and intervention upon modifiable risk factors may ameliorate HCC development and HCC morbidity in Hispanic patients.