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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 18, 2017; 9(5): 252-262
Published online Feb 18, 2017. doi: 10.4254/wjh.v9.i5.252
Published online Feb 18, 2017. doi: 10.4254/wjh.v9.i5.252
Efficacy and safety of telaprevir- and simeprevir-based triple therapies for older patients with chronic hepatitis C
Satoshi Yamagiwa, Shuji Terai, Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
Toru Ishikawa, Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950-1104, Japan
Nobuo Waguri, Department of Gastroenterology and Hepatology, Niigata City General Hospital, Niigata 950-1197, Japan
Soichi Sugitani, Department of Gastroenterology and Hepatology, Tachikawa General Hospital, Nagaoka 940-8621, Japan
Hiroto Wakabayashi, Department of Gastroenterology and Hepatology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan
Shogo Ohkoshi, Department of Internal Medicine, Nippon Dental University Medical Hospital, Niigata 951-8580, Japan
Takashi Tsukishiro, Department of Internal Medicine, Itoigawa General Hospital, Itoigawa 941-8502, Japan
Toru Takahashi, Department of Internal Medicine, Uonuma Hospital, Ojiya 947-0028, Japan
Toshiaki Watanabe, Watanabe Clinic, Sanjyo 955-0845, Japan
Author contributions: Yamagiwa S, Ishikawa T, Waguri N and Terai S contributed to study conception and design; Yamagiwa S, Sugitani S, Wakabayashi H, Ohkoshi S, Tsukishiro T, Takahashi T and Watanabe T contributed to data acquisition, data analysis and interpretation; Yamagiwa S and Terai S contributed to drafting the article; all authors contributed to making critical revisions related to important intellectual content of the manuscript; all authors contributed to final approval of the version of the article to be published.
Supported by Grants-in-Aid for Scientific Research (C) (to Yamagiwa S) from Japan Society for the Promotion of Science (JSPS) , No. 15K08991 .
Institutional review board statement: The study was reviewed and approved by Niigata University Medical and Dental Hospital Institutional Review Board.
Informed consent statement: Written informed consent under institutional review board-approved protocols (approval no. 1474) at Niigata University Medical and Dental Hospital was appropriately obtained from all the individuals enrolled in the study.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Satoshi Yamagiwa, MD, PhD, Associate Professor, Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. syamagi@med.niigata-u.ac.jp
Telephone: +81-25-2272207 Fax: +81-25-2270776
Received: August 22, 2016
Peer-review started: August 24, 2016
First decision: September 27, 2016
Revised: December 29, 2016
Accepted: January 11, 2017
Article in press: January 14, 2017
Published online: February 18, 2017
Processing time: 178 Days and 14.4 Hours
Peer-review started: August 24, 2016
First decision: September 27, 2016
Revised: December 29, 2016
Accepted: January 11, 2017
Article in press: January 14, 2017
Published online: February 18, 2017
Processing time: 178 Days and 14.4 Hours
Core Tip
Core tip: We evaluated the efficacy and safety of telaprevir (TVR)-and simeprevir (SMV)-based triple therapies for elderly patients with chronic hepatitis C, especially patients aged 66 years or older, in a real-world clinical setting. In both the TVR and SMV groups, no significant differences in the SVR and adverse events resulting in treatment discontinuation were found between the younger (aged ≤ 65) and older (aged > 65) patients. Both the TVR- and SMV-based triple therapies can be successfully used to treat patients aged 66 years or older with chronic hepatitis C virus genotype 1b infection. Genotyping of the interleukin-28B indicates a potential to achieve SVR in these difficult-to-treat elderly patients.