Case Control Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 18, 2017; 9(26): 1101-1107
Published online Sep 18, 2017. doi: 10.4254/wjh.v9.i26.1101
Regional differences in genetic susceptibility to non-alcoholic liver disease in two distinct Indian ethnicities
Govardhan Bale, Avanthi Urmila Steffie, Vishnubhotla Venkata Ravi Kanth, Padaki Nagaraja Rao, Mithun Sharma, Mitnala Sasikala, Duvvur Nageshwar Reddy
Govardhan Bale, Avanthi Urmila Steffie, Vishnubhotla Venkata Ravi Kanth, Mitnala Sasikala, Asian Healthcare Foundation, Hyderabad 500082, Telangana, India
Padaki Nagaraja Rao, Mithun Sharma, Duvvur Nageshwar Reddy, Asian Institute of Gastroenterology, Hyderabad 500082, India
Author contributions: Bale G and Steffie AU performed research; Rao PN, Sharma M and Reddy DN recruited patients; Ravi Kanth VV, Sasikala M and Rao PN designed the research; Ravi Kanth VV monitored the study, performed statistical analyses, and drafted the manuscript.
Institutional review board statement: The study was reviewed and approved by Institutional review (Scientific) board (AIG/AHF IRB: 16/2014) of Asian Institute of Gastroenterology.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None to declare.
Data sharing statement: No additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dr. Vishnubhotla Venkata Ravi Kanth, Group Leader-Genetics, Asian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad 500082, Telangana, India.
Telephone: +91-40-23378888 Fax: +91-40-23324255
Received: April 27, 2017
Peer-review started: April 28, 2017
First decision: May 23, 2017
Revised: June 29, 2017
Accepted: July 7, 2017
Article in press: July 10, 2017
Published online: September 18, 2017
Core Tip

Core tip: Non-alcoholic fatty liver disease has become the leading cause of liver damage contributing to considerable mortality. The spectrum spans from simple steatosis, through non alcoholic steatohepatitis, fibrosis, cirrhosis and finally to hepatocellular carcinoma. Genetic variants have now been recognized to contribute to a substantial extent to the onset of the disease. Reliable genetic markers that confer susceptibility to the disease have to be identified for better management of the disease. Identification of at risk individuals at a younger age by screening for genetic susceptibility will aid in better management by early interventions and lifestyle changes. This study identified regional differences and ethnicity based genetic susceptibility for non-alcoholic liver disease.