Published online Sep 18, 2017. doi: 10.4254/wjh.v9.i26.1101
Peer-review started: April 28, 2017
First decision: May 23, 2017
Revised: June 29, 2017
Accepted: July 7, 2017
Article in press: July 10, 2017
Published online: September 18, 2017
Core tip: Non-alcoholic fatty liver disease has become the leading cause of liver damage contributing to considerable mortality. The spectrum spans from simple steatosis, through non alcoholic steatohepatitis, fibrosis, cirrhosis and finally to hepatocellular carcinoma. Genetic variants have now been recognized to contribute to a substantial extent to the onset of the disease. Reliable genetic markers that confer susceptibility to the disease have to be identified for better management of the disease. Identification of at risk individuals at a younger age by screening for genetic susceptibility will aid in better management by early interventions and lifestyle changes. This study identified regional differences and ethnicity based genetic susceptibility for non-alcoholic liver disease.