Prospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 18, 2017; 9(23): 1001-1007
Published online Aug 18, 2017. doi: 10.4254/wjh.v9.i23.1001
MicroRNAs and clinical implications in hepatocellular carcinoma
Amal Ahmed Mohamed, Zainab A Ali-Eldin, Tamer A Elbedewy, Magdy El-Serafy, Fatma A Ali-Eldin, Hossameldin AbdelAziz
Amal Ahmed Mohamed, Biochemistry Department, National Hepatology and Tropical Medicine Research Institute, Cairo 11796, Egypt
Zainab A Ali-Eldin, Hossameldin AbdelAziz, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo 11331, Egypt
Tamer A Elbedewy, Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta 31111, Egypt
Magdy El-Serafy, Department of Tropical Medicine, Faculty of Medicine, Cairo University, Cairo 11796, Egypt
Fatma A Ali-Eldin, Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo 11331, Egypt
Author contributions: Mohamed AA designed the research; Ali-Eldin ZA, Elbedewy TA and Ali-Eldin FA performed the clinical part of the research; Mohamed AA performed the biochemical part of the work; Elbedewy TA performed statistical analysis of the data; Ali-Eldin ZA, Elbedewy TA and Ali-Eldin FA wrote the paper; El-Serafy M and AbdelAziz H revised the paper.
Institutional review board statement: The study was approved.
Informed consent statement: All study participants, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Amal Ahmed Mohamed, Assistant Professor of Biochemistry and Molecular Biology, Biochemistry Department, National Hepatology and Tropical Medicine Research Institute, 10 Kasar El Eini Street, Cairo 11796, Egypt. amalahmedhcp@yahoo.com
Telephone: +20-2-23649005 Fax: +20-2-23649005
Received: February 14, 2017
Peer-review started: February 17, 2017
First decision: April 20, 2017
Revised: May 31, 2017
Accepted: June 19, 2017
Article in press: June 20, 2017
Published online: August 18, 2017
Processing time: 184 Days and 14.2 Hours
Core Tip

Core tip: MicroRNA is promising as diagnostic and prognostic biomarkers. miR-23a can be used in screening of hepatocellular carcinoma (HCC) and it gives better results than alpha fetoprotein. It is also related to more progressive HCC so it can be used as predictor of prognosis.