Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 8, 2017; 9(22): 967-972
Published online Aug 8, 2017. doi: 10.4254/wjh.v9.i22.967
Published online Aug 8, 2017. doi: 10.4254/wjh.v9.i22.967
Serum cholinesterase: A predictive biomarker of hepatic reserves in chronic hepatitis D
Minaam Abbas, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0SP, United Kingdorm
Minaam Abbas, Zaigham Abbas, Department of Medicine, Orthopedic and Medical Institute, Karachi 74400, Pakistan
Author contributions: Abbas M was responsible for the study conception and design; Abbas Z identified patients for the study; both authors contributed to the data analysis, interpretation and manuscript drafting; and they critically reviewed the paper and approved the final version to be submitted for publication.
Institutional review board statement: Retrospective chart reviews were approved by the Ethics Review Committee of OMI.
Conflict-of-interest statement: The authors declare no potential conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Zaigham Abbas, FCPS, FRCP, Department of Medicine, Orthopedic and Medical Institute, Depot Lines, Karachi 74400, Pakistan. drzabbas@gmail.com
Telephone: +92-21-32226214 Fax: +92-21-32251814
Received: January 18, 2017
Peer-review started: January 20, 2017
First decision: March 13, 2017
Revised: March 19, 2017
Accepted: June 12, 2017
Article in press: June 13, 2017
Published online: August 8, 2017
Processing time: 200 Days and 15.2 Hours
Peer-review started: January 20, 2017
First decision: March 13, 2017
Revised: March 19, 2017
Accepted: June 12, 2017
Article in press: June 13, 2017
Published online: August 8, 2017
Processing time: 200 Days and 15.2 Hours
Core Tip
Core tip: Prognostic models to assess liver function in patients with chronic liver disease are used extensively in clinical settings. These systems employ multiple clinical and laboratory parameters to evaluate liver reserves and predict outcome. In our study we assessed cholinesterase as an independent predictor of hepatic reserves. We found that its values correlated strongly with Liver function tests and with the existing scoring models. Thereafter, we defined optimal cholinesterase levels corresponding to the different stages and classes of the scoring systems and hence the severity of chronic liver disease. The study’s subjects were patients suffering from cirrhosis due to hepatitis D.