Performance of cold-preserved rat liver Microorgans as the biological component of a simplified prototype model of bioartificial liver
María Dolores Pizarro, Joaquín Valentín Rodríguez, Centro Binacional de Criobiología Clínica y Aplicada, Rosario 2000, Argentina
María Gabriela Mediavilla, Instituto de Biología Molecular y Celular de Rosario, Rosario 2000, Argentina
María Gabriela Mediavilla, Joaquín Valentín Rodriguez, María Eugenia Mamprin, Consejo Nacional de Investigaciones Científicas y Técnicas, Caba C1033AAJ, Argentina
Alejandra Beatriz Quintana, Morfología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario 2000, Argentina
María Eugenia Mamprin, Ángel Luis Scandizzi, Área Farmacología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario S2002 LRK, Argentina
Author contributions: Pizarro MD performed the majority of experiments and analyzed the data; Mediavilla MG and Mamprin ME have designed research, performed research, contributed new reagents, analyzed data, wrote the manuscript; all the authors were involved in reviewing the literature for latest contributions in the field, writing, and edition of the manuscript; Mediavilla MG and Mamprin ME have equally contributed to this work.
Supported by Universidad Nacional de Rosario (UNR), No. 677/2013.
Institutional review board statement: The study was reviewed and approved by the National University of Rosario Institutional Review Board (Resol. C.S., No. 677/2013).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Faculty of Biochemical and Pharmaceutical Sciences-UNR (Resol. No. 139/2011).
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: María Eugenia Mamprin, PhD, Professor of Pharmacology, Área Farmacología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario S2002 LRK, Argentina. email@example.com
Received: May 31, 2016
Peer-review started: June 1, 2016
First decision: July 20, 2016
Revised: July 28, 2016
Accepted: September 13, 2016
Article in press: September 18, 2016
Published online: November 28, 2016