©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Changes in cellular proliferation and plasma products are associated with liver failure
Juliana Gil Melgaço, Leonardo Assaf Pinheiro, Claudia Lamarca Vitral, Departamento de Microbiologia e Parasitologia, Universidade Federal Fluminense, Niterói 20550-013, Brazil
Juliana Gil Melgaço, Yasmine Rangel Vieira, Jaqueline Mendes de Oliveira, Marcelo Alves Pinto, Instituto Oswaldo Cruz/Fiocruz, Laboratório de Desenvolvimento Tecnológico em Virologia, Rio de Janeiro 21040-900, Brazil
Frederico Marianetti Soriani, Pedro Henrique Ferreira Sucupira, Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil
Lia Laura Lewis-Ximenez, Instituto Oswaldo Cruz/Fiocruz, Ambulatório de Hepatites Virais, Rio de Janeiro 21040-900, Brazil
Cristina Carvalho Vianna Araújo, Lúcio Filgueiras Pacheco-Moreira, Hospital Federal de Bonsucesso, Rio de Janeiro 21041-030, Brazil
Gustavo Batista Menezes, Laboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil
Oswaldo Gonçalves Cruz, Fundação Oswaldo Cruz, Programa de Computação Científica, Rio de Janeiro 21040-900, Brazil
Author contributions: All authors have seen and approved the content of the manuscript and contributed meaningfully to the work. In summary, Melgaço JG conceived the study, performed the experiments, analyzed the data and wrote the manuscript; Pinheiro LA, Vieira YR, de Oliveira JM and Vitral CL acquired the data for cytokine quantification, serological data and the virological marker assay; de Oliveira JM reviewed the analysis and wrote the manuscript; Lewis-Ximenez LL collected the clinical data and the samples from the self-limited acute hepatitis patients and healthy subjects; Araújo CCV and Pacheco-Moreira LF collected the clinical data and the samples from the acute liver failure patients; Soriani FM, Sucupira PHF and Menezes GB performed the DNA extraction and quantified the mitochondrial DNA using molecular biology assays; Cruz OG performed the statistical analysis; Vitral CL and Pinto MA participated in the study design and coordination; Pinto MA participated in the analysis of data and the preparation of the manuscript.
Supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq, No. 308951/2010-7; and the Fundação de Amparo à Pesquisas no Rio de Janeiro - Faperj, No. E-26/110.848/2013.
Institutional review board statement: The study protocol was approved by the National Commission on Ethics in Research (CONEP) and by the institutional review board of the Oswaldo Cruz Foundation, FIOCRUZ (222/03).
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Juliana Gil Melgaço, PhD, Instituto Oswaldo Cruz/Fiocruz, Laboratório de Desenvolvimento Tecnológico em Virologia, Fundação Oswaldo Cruz/FIOCRUZ, Avenida Brasil, 4365, pavilhão Hélio e Peggy Pereira, Rio de Janeiro 21040-900, Brazil. email@example.com
Telephone: +55-21-25621711 Fax: +55-21-25621898
Received: May 23, 2016
Peer-review started: May 25, 2016
First decision: July 20, 2016
Revised: August 3, 2016
Accepted: September 13, 2016
Article in press: September 18, 2016
Published online: November 18, 2016