Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model
Sylvie Lagaye, Jesintha Gaston, Stanislas Pol, Institut Pasteur, INSERM U1223, 75015 Paris, France
Sylvie Lagaye, Jesintha Gaston, Hong Shen, Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes (UMR S1016), 75014 Paris, France
Sonia Brun, Clarisse Dubray, Jerôme Courcambeck, Firas Bassisi, Philippe Halfon, Genoscience Pharma, 13006 Marseille, France
Ruzena Stranska, KU Leuven, Rega Institute, 3000 Leuven, Belgium
Claire Camus, Philippe Halfon, Laboratoire Alphabio, 13006 Marseille, France
Géraldine Rousseau, APHP, Groupe Hospitalier La Pitié Salpétrière, Service de Chirurgie digestive et Hépato bilio pancréatique, 75013 Paris, France
Pierre-Philippe Massault, APHP, Groupe Hospitalier Cochin, Service de Chirurgie digestive, Hépato-biliaire et Endocrinienne, 75014 Paris, France
Stanislas Pol, Université Paris Descartes, 75014 Paris, France
Stanislas Pol, APHP, Groupe Hospitalier Cochin, Unité d’Hépatologie, 75014 Paris, France
Stanislas Pol, Institut Pasteur, Département de Recherche Translationnelle, INSERM UMS20, 75015 Paris, France
Author contributions: Lagaye S wrote the paper; Lagaye S, Brun S, Gaston J, Shen H, Stranska R, Camus C, Dubray C, Rousseau G, Massault PP, Courcambeck J and Bassisi F performed the experiments; Lagaye S, Brun S, Camus C, Halfon P and Pol S analyzed the data; Lagaye S, Halfon P and Pol S conceived and designed the experiments; Halfon P and Pol S contributed equally to the work.
Supported by The Institut National de la Santé et de la Recherche Médicale (INSERM, France); and the personal support of Professor Jean-François Delfraissy as Director of the French Agency, Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS).
Institutional review board statement: Institutional review board statement is not required for manuscript submission in our Institution.
Institutional animal care and use committee statement: No animal use in the experiments.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: No data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sylvie Lagaye, PhD, DSc, Senior Scientist, Institut Pasteur, INSERM U1223, 25-28 rue du Dr Roux, 75015 Paris, France. firstname.lastname@example.org
Telephone: +33-1-40613424 Fax: +33-1-45688548
Received: March 24, 2016
Peer-review started: April 6, 2016
First decision: May 16, 2016
Revised: June 1, 2016
Accepted: June 27, 2016
Article in press: June 29, 2016
Published online: July 28, 2016