Correa CG, Colombo BDS, Ronsoni MF, Soares e Silva PE, Fayad L, Silva TE, Wildner LM, Bazzo ML, Dantas-Correa EB, Narciso-Schiavon JL, Schiavon LL. Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis. World J Hepatol 2016; 8(17): 739-748 [PMID: 27330683 DOI: 10.4254/wjh.v8.i17.739]
Corresponding Author of This Article
Dr. Leonardo de Lucca Schiavon, Division of Gastroenterology, Federal University of Santa Catarina, Rua Deputado Antonio Edu Vieira 1310, casa 217, Bairro Pantanal, Florianópolis, Santa Catarina 88.040-001, Brazil. leo-jf@uol.com.br
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jun 18, 2016; 8(17): 739-748 Published online Jun 18, 2016. doi: 10.4254/wjh.v8.i17.739
Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis
Carina Gabriela Correa, Bruno da Silveira Colombo, Marcelo Fernando Ronsoni, Pedro Eduardo Soares e Silva, Leonardo Fayad, Telma Erotides Silva, Letícia Muraro Wildner, Maria Luiza Bazzo, Esther Buzaglo Dantas-Correa, Janaína Luz Narciso-Schiavon, Leonardo de Lucca Schiavon
Carina Gabriela Correa, Bruno da Silveira Colombo, Marcelo Fernando Ronsoni, Pedro Eduardo Soares e Silva, Leonardo Fayad, Telma Erotides Silva, Esther Buzaglo Dantas-Correa, Janaína Luz Narciso-Schiavon, Leonardo de Lucca Schiavon, Division of Gastroenterology, Federal University of Santa Catarina, Florianópolis, Santa Catarina 88.040-001, Brazil
Letícia Muraro Wildner, Maria Luiza Bazzo, Department of Clinical Analysis, Federal University of Santa Catarina, Florianópolis, Santa Catarina 88.040-970, Brazil
Author contributions: Narciso-Schiavon JL and Schiavon LL designed the research; Correa CG, Colombo BS, Ronsoni MF, Soares e Silva PE, Fayad L, Silva TE and Dantas-Correa EB performed the research; Wildner LM and Bazzo ML contributed with the specific laboratory analysis and sample handling; Correa CG and Schiavon LL analyzed the data and wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Federal University of Santa Catarina Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Nothing to report.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at leo-jf@uol.com.br. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Leonardo de Lucca Schiavon, Division of Gastroenterology, Federal University of Santa Catarina, Rua Deputado Antonio Edu Vieira 1310, casa 217, Bairro Pantanal, Florianópolis, Santa Catarina 88.040-001, Brazil. leo-jf@uol.com.br
Telephone: +55-48-32096854 Fax: +55-48-32096854
Received: February 26, 2016 Peer-review started: February 26, 2016 First decision: March 23, 2016 Revised: May 3, 2016 Accepted: May 17, 2016 Article in press: May 27, 2016 Published online: June 18, 2016 Processing time: 109 Days and 10.7 Hours
Core Tip
Core tip: Insulin-like growth factor-binding protein 3 (IGFBP-3) levels are decreased in cirrhosis and seem to correlate with the intensity of hepatic dysfunction, but its prognostic significance is uncertain. In this prospective cohort study, IGFBP-3 levels correlated with variables associated with the intensity of liver dysfunction in both outpatients with stable cirrhosis and in subjects hospitalized for acute decompensation. IGFBP-3 levels increased significantly after discharge and after liver transplantation. Lower IGFBP-3 levels were associated with poor outcomes in both outpatients with stable cirrhosis and in those hospitalized for acute decompensation, suggesting that it can be used in clinical practice as a prognostic biomarker in cirrhosis.
