Case Report
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 18, 2016; 8(11): 530-532
Published online Apr 18, 2016. doi: 10.4254/wjh.v8.i11.530
Management of pregnancy in Crigler Najjar syndrome type 2
Alisha Nitin Chaubal, Ruchir Patel, Dhaval Choksi, Kaivan Shah, Meghraj Ingle, Prabha Sawant
Alisha Nitin Chaubal, Ruchir Patel, Dhaval Choksi, Kaivan Shah, Meghraj Ingle, Prabha Sawant, Department of Gastroenterology, LTMG Hospital, Mumbai 400022, India
Author contributions: Chaubal AN wrote the case report; Chaubal AN, Patel R, Choksi D, Shah K, Ingle M and Sawant P managed the case.
Institutional review board statement: The institutional review board of LTMG hospital have reviewed and accepted the case report.
Informed consent statement: I am aware that my clinical problem is being reported without revealing my identity and I have no objections to the same. I have been explained in detail the procedure for the same and will not hold anyone responsible for the outcome.
Conflict-of-interest statement: The authors do not hold any conflict of interest with reviewers.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alisha Nitin Chaubal, Registrar, Department of Gastroenterology, LTMGH Hospital, Dr. Babasaheb Ambedkar Road, Sion West, Mumbai 400022, India. alishachaubal@gmail.com
Telephone: +91-022-24063088 Fax: +91-022-24044154
Received: October 18, 2015
Peer-review started: November 12, 2015
First decision: January 4, 2016
Revised: February 22, 2016
Accepted: March 9, 2016
Article in press: March 14, 2016
Published online: April 18, 2016
Processing time: 151 Days and 9.1 Hours
Core Tip

Core tip: Crigler Najjar syndrome type 2 is a rare disorder causing indirect hyperbilirubinemia. In pregnancy placental crossing of unconjugated bilirubin can cause high bilirubin levels in the fetus with low Uridine Di Phospho Glucoronosyl Transferase activity causing permanent neurological impairment in the newborn. Hence timely diagnosis and treatment with low dose phenobarbitone is required.