Nakamoto S, Kanda T, Shirasawa H, Yokosuka O. Antiviral therapies for chronic hepatitis C virus infection with cirrhosis. World J Hepatol 2015; 7(8): 1133-1141 [PMID: 26052402 DOI: 10.4254/wjh.v7.i8.1133]
Corresponding Author of This Article
Tatsuo Kanda, MD, PhD, Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. kandat-cib@umin.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Shingo Nakamoto, Tatsuo Kanda, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba 260-8670, Japan
Shingo Nakamoto, Hiroshi Shirasawa, Department of Molecular Virology, Chiba University, Graduate School of Medicine, Chiba 260-8670, Japan
Author contributions: Nakamoto S, Kanda T, Shirasawa H and Yokosuka O all equally contributed to this paper.
Conflict-of-interest: Tatsuo Kanda reports receiving lecture fees from Chugai Pharmaceutical, MSD, Tanabe-Mitsubishi, Ajinomoto, Bristol-Myers Squibb, Daiichi-Sankyo, Janssen Pharmaceutical and GlaxoSmithKline; Osamu Yokosuka reports receiving grant support from Chugai Pharmaceutical, Bayer, MSD, Daiichi-Sankyo, Tanabe-Mitsubishi, Bristol-Myers Squibb, Gilead Sciences and Taiho Pharmaceutical; the other authors have no conflict of interest statement.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tatsuo Kanda, MD, PhD, Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. kandat-cib@umin.ac.jp
Telephone: +81-43-2262086 Fax: +81-43-2262088
Received: September 7, 2014 Peer-review started: September 10, 2014 First decision: December 26, 2014 Revised: January 8, 2015 Accepted: February 4, 2015 Article in press: February 9, 2015 Published online: May 18, 2015 Processing time: 253 Days and 23.6 Hours
Core Tip
Core tip: In general, patients with cirrhosis who are infected with hepatitis C virus (HCV) are at a higher risk for the development of hepatocellular carcinoma (HCC) compared with patients without cirrhosis. Antiviral treatments for patients with cirrhosis and HCV may reduce the occurrence of HCC and/or prevent the progression to hepatic failure. In this review, we discussed the sustained virological response (SVR) rates of interferon-containing and interferon-free regimens for these patients. Recent advances in the development of direct-acting antivirals against HCV have improved the SVR rates and have reduced the occurrence of adverse events during treatment. Interferon-free regimens might improve the prognosis of patients with cirrhosis and HCV.
