Observational Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. May 8, 2015; 7(7): 1001-1006
Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.1001
Mean platelet volume as a novel predictor of systemic inflammatory response in cirrhotic patients with culture-negative neutrocytic ascites
Marisol Gálvez-Martínez, Alfredo I Servín-Caamaño, Eduardo Pérez-Torres, Francisco Salas-Gordillo, Xaira Rivera-Gutiérrez, Fátima Higuera-de la Tijera
Marisol Gálvez-Martínez, Eduardo Pérez-Torres, Francisco Salas-Gordillo, Fátima Higuera-de la Tijera, Gastroenterology Department, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City 06720, Mexico
Alfredo I Servín-Caamaño, Internal Medicine Department, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City 06720, Mexico
Xaira Rivera-Gutiérrez, Faculty of Medicine, “Universidad Veracruzana”, Veracruz 91090, Mexico
Author contributions: Gálvez-Martínez M contributed with the acquisition, analysis and interpretation of data, and contributed with the manuscript drafting; Servín-Caamaño AI and Pérez-Torres E contributed with the acquisition, analysis and interpretation of data; Salas-Gordillo F contributed with the acquisition of data; Rivera-Gutiérrez X made grammatical corrections and edited the final manuscript; Higuera-de la Tijera F provided technical and material support, provided the concept and design of the study, supervised the study, and contributed with the manuscript drafting; all authors read and approved the final manuscript.
Supported by Hospital General de México Dr. Eduardo Liceaga.
Ethics approval: The study was reviewed and approved by the Gastroenterology Department, Hospital General de México “Dr. Eduardo Liceaga”. Institutional Review Board.
Informed consent: All study participants, or their legal guardian, were contacted via telephone f in order to use data from their medical records.
Conflict-of-interest: The authors have not conflict of interest to declare. None of the researchers involved in the present study have received fees for serving as a speaker, consultant or as advisory board member for any organization.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding author at fatimahiguera@yahoo.com.mx. Consent for data sharing was not obtained but the present data are anonymized and risk of identification is low. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fátima Higuera-de la Tijera, MD, MSc, Gastroenterology Department, Hospital General de México “Dr. Eduardo Liceaga”, Dr. Balmis 148, Mexico City 06720, Mexico. fatimahiguera@hotmail.com
Telephone: +52-55-27892000-1358
Received: January 14, 2015
Peer-review started: January 16, 2015
First decision: February 7, 2015
Revised: February 21, 2015
Accepted: April 1, 2015
Article in press: April 7, 2015
Published online: May 8, 2015
Core Tip

Core tip: To suspect and recognize promptly those patients with ascites fluid infection (AFI) is crucial. Systemic inflammatory response syndrome and clinical signs are not always present in cirrhotic patients with AFI, and gold standard tests for diagnosis, such as neutrophils count and ascites cultures are not always quickly available in many clinical settings. The mean platelet volume (MPV) is a very good predictor of systemic inflammatory response. A MPV cutoff value equal or greater than 8.3 fl predicts the presence of AFI particularl culture-negative neutrocytic ascites.