Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 18, 2015; 7(5): 814-818
Published online Apr 18, 2015. doi: 10.4254/wjh.v7.i5.814
Unusual case of B cell lymphoma after immunosuppressive treatment for psoriasis
Lorenzo Nosotti, Andrea Baiocchini, Claudio Bonifati, Ubaldo Visco-Comandini, Concetta Mirisola, Franca Del Nonno
Lorenzo Nosotti, Concetta Mirisola, Gastrointestinal and Liver Department, National Institute for Health, Migration and Poverty, 00153 Rome, Italy
Andrea Baiocchini, Ubaldo Visco-Comandini, Franca Del Nonno, Infectious Diseases Department, National Institute for Infectious Diseases “L. Spallanzani”, 00149 Rome, Italy
Claudio Bonifati, Department of Inflammatory Skin Diseases, San Gallicano Dermatologic Institute (IRCCS), 00144 Rome, Italy
Author contributions: All the authors contributed to this paper.
Ethics approval: This case report conforms to Good Clinical Practice and to the World Medical Association Declaration of Helsinki. It has been approved by the institutional review board of National Institute for Health, Migration and Poverty.
Informed consent: The person involved in this case report gave his informed consent prior to his inclusion in the study. Details that might disclose the identity of the subject under study have been omitted.
Conflict-of-interest: None competing or conflicts of interests declared.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dr. Lorenzo Nosotti, Gastrointestinal and Liver Department, National Institute for Health, Migration and Poverty, via San Gallicano 25a, 00153 Rome, Italy.
Telephone: +39-06-58543642 Fax: +39-06-58543730
Received: October 21, 2014
Peer-review started: October 22, 2014
First decision: December 22, 2014
Revised: January 26, 2015
Accepted: March 18, 2015
Article in press: March 20, 2015
Published online: April 18, 2015
Core Tip

Core tip: We report a case of a rare T cell/histiocyte- rich large B cell lymphoma localized to liver, gastro-intestinal tract and spleen in a patient with psoriasis treated with traditional immunosuppressant drugs followed by anti-tumor necrosis factor-α therapy. Liver and spleen involvement mimicked at the beginning an inflammatory disease causing a delayed diagnosis of malignancy. We think that abdominal ultrasound evaluation need to be included in the pre-treatment screening as in the follow-up surveillance in psoriatic patients treated with biologic immunosuppressive agents.