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World J Hepatol. Apr 8, 2015; 7(4): 696-702
Published online Apr 8, 2015. doi: 10.4254/wjh.v7.i4.696
Host cellular microRNA involvement in the control of hepatitis B virus gene expression and replication
Yoshiaki Mizuguchi, Toshihiro Takizawa, Eiji Uchida
Yoshiaki Mizuguchi, Eiji Uchida, Department of Surgery, Nippon Medical School Hospital, Bunkyo-Ku, Tokyo 113-8603, Japan
Toshihiro Takizawa, Department of Anatomy, Nippon Medical School, Bunkyo-Ku, Tokyo 113-8603, Japan
Author contributions: Takizawa T and Uchida E contributed equally to this work for generating the figures and revising the manuscript; Mizuguchi Y contributed to the writing of the manuscript.
Conflict-of-interest: The authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yoshiaki Mizuguchi, MD, PhD, Department of Surgery, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo 113-8603, Japan. yoshi1224@gmail.com
Telephone: +81-3-38222131 Fax: + 81-3-58146135
Received: September 17, 2014
Peer-review started: September 20, 2014
First decision: October 28, 2014
Revised: November 28, 2014
Accepted: January 15, 2015
Article in press: January 19, 2015
Published online: April 8, 2015
Processing time: 208 Days and 21.3 Hours
Core Tip

Core tip: A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. miRNAs are thought to exert a profound effect on almost every aspect of biology and pathology. In this review, we focused on the miRNAs that play an important role in hepatitis B virus replication and gene expression, and summarized the involvement of host cellular miRNAs that are directly and indirectly associated with hepatitis B virus (HBV) RNA or HBV associated transcription factors.