Rabelo-Gonçalves EM, Roesler BM, Zeitune JM. Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. World J Hepatol 2015; 7(30): 2968-2979 [PMID: 26730276 DOI: 10.4254/wjh.v7.i30.2968]
Corresponding Author of This Article
Elizabeth MA Rabelo-Gonçalves, BSc, MSc, Laboratory of Gastroenterology and Hepatology, Center of Diagnosis of Digestive Diseases, State University of Campinas, Rua Carlos Chagas 420, Campinas, São Paulo 13083-878, Brazil. elizabeth.goncalves@gc.unicamp.br
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Dec 28, 2015; 7(30): 2968-2979 Published online Dec 28, 2015. doi: 10.4254/wjh.v7.i30.2968
Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases
Elizabeth MA Rabelo-Gonçalves, Bruna M Roesler, José MR Zeitune
Elizabeth MA Rabelo-Gonçalves, Bruna M Roesler, Laboratory of Gastroenterology and Hepatology, Center of Diagnosis of Digestive Diseases, State University of Campinas, Campinas, São Paulo 13083-878, Brazil
José MR Zeitune, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo13083-887, Brazil
Author contributions: Rabelo-Gonçalves EMA contributed to the study idea, study design, literature search, manuscript writing and final revision of the article; Roesler BM contributed to the literature search, manuscript writing and final revision of the article; Zeitune JMR contributed to study design, manuscript writing and the final version of the article.
Conflict-of-interest statement: The authors declare no conflict of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Elizabeth MA Rabelo-Gonçalves, BSc, MSc, Laboratory of Gastroenterology and Hepatology, Center of Diagnosis of Digestive Diseases, State University of Campinas, Rua Carlos Chagas 420, Campinas, São Paulo 13083-878, Brazil. elizabeth.goncalves@gc.unicamp.br
Telephone: +55-19-35218557 Fax: +55-19-35218566
Received: April 27, 2015 Peer-review started: May 4, 2015 First decision: July 6, 2015 Revised: November 26, 2015 Accepted: December 13, 2015 Article in press: December 15, 2015 Published online: December 28, 2015 Processing time: 243 Days and 15.7 Hours
Core Tip
Core tip:Helicobacter pylori (H. pylori) has been associated with several extragastric manifestations, including liver and pancreas diseases. Evidence for its role in the pathogenesis of chronic liver diseases and liver carcinoma is supported by several clinical and experimental studies. Furthermore, epidemiologic and serology-based works have reported a possible association between the microorganism and pancreatic cancer. H. pylori infection has also been linked to the acute and chronic pancreatitis pathogenesis and it could be related to the development of autoimmune pancreatitis, diabetes mellitus and metabolic syndrome. This review summarizes recent findings on the possible role of H. pylori infection in the etiology of liver and pancreas disorders.
