Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Nov 18, 2015; 7(26): 2696-2702
Published online Nov 18, 2015. doi: 10.4254/wjh.v7.i26.2696
Pseudolymphoma (reactive lymphoid hyperplasia) of the liver: A clinical challenge
Yong Kyong Kwon, Reena C Jha, Kambiz Etesami, Thomas M Fishbein, Metin Ozdemirli, Chirag S Desai
Yong Kyong Kwon, Kambiz Etesami, Thomas M Fishbein, Chirag S Desai, Transplant Institute, MedStar Georgetown University Hospital, Washington, DC 20007, United States
Reena C Jha, Department of Radiology, MedStar Georgetown University Hospital, Washington, DC 20007, United States
Metin Ozdemirli, Department of Pathology, MedStar Georgetown University Hospital, Washington, DC 20007, United States
Author contributions: All the authors contributed equally to this work with writing and editing; in addition, Ozdemirli M provided pathology images; Jha RC provided radiographic images.
Institutional review board statement: This case report was except from the institutional review board at MedStar Georgetown University Hospital.
Informed consent statement: The patients involved in this study gave their written informed consent authorizing use and disclosure of their protected health information.
Conflict-of-interest statement: All the authors have no conflicts of interests to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Chirag S Desai, MD, Transplant Institute, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20007, United States.
Telephone: +1-202-4446396 Fax: +1-877-6808192
Received: June 1, 2015
Peer-review started: June 4, 2015
First decision: August 14, 2015
Revised: September 5, 2015
Accepted: October 20, 2015
Article in press: October 27, 2015
Published online: November 18, 2015
Core Tip

Core tip: Reactive lymphoid hyperplasia of the liver also known as pseudolymphoma is an extremely rare condition. Because of its rarity, association with underlying inflammatory liver disease and close resemblance to malignant hepatic lesions such as hepatocellular carcinoma and cholangiocarcinoma on imaging studies, this rare lesion is frequently misdiagnosed. We discuss two cases of hepatic reactive lymphoid hyperplasia (RLH) in patients with autoimmune hepatitis and how we came to the correct diagnosis. Definitive diagnosis of hepatic RLH often requires surgical excision.