Published online Nov 18, 2015. doi: 10.4254/wjh.v7.i26.2648
Peer-review started: April 2, 2015
First decision: May 13, 2015
Revised: May 19, 2015
Accepted: October 14, 2015
Article in press: November 4, 2015
Published online: November 18, 2015
Core tip: Hepatocellular carcinoma (HCC) is the prominent Primary Hepatic tumor. Survival rates average between 6 and 20 mo, making Liver transplantation is the most efficient treatment. The established Milan Criteria is now widely accepted around the world for choosing patients suffering with HCC as liver transplant candidates. Due to high mortality rates, additional variables and tumor characteristics have been researched (example, University of California, San Francisco Criteria) in order to include more patients as candidates, so as to increase overall survival. In this comprehensive review, the pathophysiology, diagnostic modalities, and treatment options are thoroughly discussed.