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World J Hepatol. Sep 18, 2015; 7(20): 2309-2314
Published online Sep 18, 2015. doi: 10.4254/wjh.v7.i20.2309
Progress in the treatment of pulmonary metastases after liver transplantation for hepatocellular carcinoma
Zhan-Wang Xiang, Lin Sun, Guo-Hong Li, Rakesh Maharjan, Jin-Hua Huang, Chuan-Xing Li
Zhan-Wang Xiang, Lin Sun, Guo-Hong Li, Rakesh Maharjan, Jin-Hua Huang, Chuan-Xing Li, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong Province, China
Author contributions: Xiang ZW and Sun L contributed equally to this work; Li CX and Huang JH designed research; Xiang ZW, Sun L, Li GH and Li CX performed research; Xiang ZW, Sun L and Maharjan R analyzed data; Xiang ZW and Sun L wrote the paper; all authors had read and approved the final manuscript to be published.
Supported by National Natural Science Foundation of China, No. 81371652 (to Huang JH).
Conflict-of-interest statement: The authors declare there is no conflict of interest in this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chuan-Xing Li, MD, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, No. 651 Dongfeng East Road, Guangzhou 510060, Guangdong Province, China. lichuanh@mail.sysu.edu.cn
Telephone: +86-20-87343901 Fax: +86-20-87343901
Received: April 16, 2015
Peer-review started: April 19, 2015
First decision: June 2, 2015
Revised: June 19, 2015
Accepted: September 2, 2015
Article in press: September 7, 2015
Published online: September 18, 2015
Processing time: 151 Days and 18.9 Hours
Core Tip

Core tip: The treatment of pulmonary metastases after liver transplantation for hepatocellular carcinoma has become a hot research topic. Although single conventional treatment (chemotherapy, surgery and external beam radiation therapy), image-guided minimally invasive therapy (radiofrequency ablation, microwave ablation, cryoablation, and brachytherapy) and molecular targeted drugs have had a significant effect, patients do not have durable remission and the long-term survival rate is disappointing. Therefore, we reviewed single conventional treatments, new treatments, and combination therapy, to provide a basis for the best treatment of these patients.