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Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2015; 7(2): 226-234
Published online Feb 27, 2015. doi: 10.4254/wjh.v7.i2.226
Micro RNAs in the development of non-alcoholic fatty liver disease
Glenn S Gerhard, Johanna K DiStefano
Glenn S Gerhard, Department of Medical Genetics and Molecular Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, United States
Johanna K DiStefano, Diabetes, Cardiovascular and Metabolic Diseases Division, Translational Genomics Research Institute, Phoenix, AZ 85004, United States
Author contributions: Gerhard GS and Distefano JK contributed to this paper.
Supported by The National Institutes of Health DK091601 (JKD and GSG), P30 DK072488 (GSG and CDS); and the Translational Genomics Research Institute.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Johanna K DiStefano, PhD, Diabetes, Cardiovascular and Metabolic Diseases Division, Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, AZ 85004, United States. jdistefano@tgen.org
Telephone: +1-602-3438812 Fax: +1-602-3438844
Received: August 16, 2014
Peer-review started: August 17, 2014
First decision: September 28, 2014
Revised: October 28, 2014
Accepted: November 17, 2014
Article in press: November 19, 2014
Published online: February 27, 2015
Core Tip

Core tip: Available data on miRNAs in nonalcoholic fatty liver disease (NAFLD) are largely derived from various cell culture and animal models. Reflecting an emerging field, little cross-model concordance is present and few human data are available for comparison with cell culture and animal model results. Although the generation of human data may be limited by the availability of tissue samples, recent reports of circulating miRNAs from NAFLD patients hold promise for significant progress for diagnosis and clinical monitoring of disease progression.