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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 8, 2015; 7(16): 2020-2028
Published online Aug 8, 2015. doi: 10.4254/wjh.v7.i16.2020
Published online Aug 8, 2015. doi: 10.4254/wjh.v7.i16.2020
Biological features and biomarkers in hepatocellular carcinoma
Tetsuhiro Chiba, Eiichiro Suzuki, Tomoko Saito, Sadahisa Ogasawara, Yoshihiko Ooka, Akinobu Tawada, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
Atsushi Iwama, Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
Author contributions: Chiba T and Suzuki E wrote the paper; Saito T, Ogasawara S, Ooka Y, Tawada A, Iwama A and Yokosuka O contributed to the paper.
Conflict-of-interest statement: The authors disclose no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tetsuhiro Chiba, MD, PhD, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. techiba@faculty.chiba-u.jp
Telephone: +81-43-2262083 Fax: +81-43-2262088
Received: April 19, 2015
Peer-review started: April 21, 2015
First decision: July 1, 2015
Revised: July 6, 2015
Accepted: July 23, 2015
Article in press: July 27, 2015
Published online: August 8, 2015
Processing time: 110 Days and 19.7 Hours
Peer-review started: April 21, 2015
First decision: July 1, 2015
Revised: July 6, 2015
Accepted: July 23, 2015
Article in press: July 27, 2015
Published online: August 8, 2015
Processing time: 110 Days and 19.7 Hours
Core Tip
Core tip: Recent progress in molecular biology enabled understanding of the mechanisms underlying hepatocarcinogenesis and identification of useful biomarkers. According to these findings, further efforts would be needed to improve understanding of these molecular mechanisms and to establish novel therapeutic approaches.