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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 18, 2015; 7(11): 1586-1594
Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1586
Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1586
Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort
Jen-Jung Pan, Chaoru Chen, Michael B Fallon, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, the University of Texas Health Science Center at Houston, Houston, TX 77030, United States
Susan P Fisher-Hoch, Joseph B McCormick, School of Public Health Brownsville Campus, the University of Texas Health Science Center at Houston, Brownsville, TX 78520, United States
Ariel E Feldstein, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California at San Diego, San Diego, CA 92123, United States
Mohammad H Rahbar, Division of Clinical and Translational Sciences, Department of Internal Medicine, the University of Texas Health Science Center at Houston, Houston, TX 77030, United States
Mohammad H Rahbar, Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, the University of Texas Health Science Center at Houston, Houston, TX 77030, United States
Laura Beretta, Department of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States
Author contributions: Pan JJ contributed to study concept and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript, approved final submission; Fisher-Hoch SP contributed to study concept and design, acquisition of data, critical revision of the manuscript, approved final submission; Chen C contributed to interpretation of data, statistical analysis, approved final submission; Feldstein AE contributed to study concept and design, critical revision of the manuscript, approved final submission; McCormick JB contributed to study concept and design, acquisition of data, critical revision of the manuscript, approved final submission; Rahbar MH contributed to critical revision of the manuscript, statistical analysis, approved final submission; Beretta L contributed to critical revision of the manuscript, approved final submission; Fallon MB contributed to study concept and design, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript, approved final submission.
Supported by MD000170 P20 funded from the National Institute on Minority Health and Health disparities (NIMHD); The Centers for Clinical and Translational Science Award 1U54RR023417-01 from the National Center for Research Resources (NCRR).
Ethics approval: The institutional review board of the University of Texas Health Science Center at Houston approved this study.
Clinical trial registration: None.
Informed consent: All involved persons gave their informed consent prior to study inclusion.
Conflict-of-interest: All authors have no conflicts of interest to declare.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding authors at jenjung.pan@uth.tmc.edu.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jen-Jung Pan, MD, PhD, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, the University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 4.234, Houston, TX 77030, United States. jenjung.pan@uth.tmc.edu
Telephone: +1-713-5006677 Fax: +1-713-5006699
Received: February 8, 2015
Peer-review started: February 9, 2015
First decision: March 20, 2015
Revised: March 31, 2015
Accepted: April 16, 2015
Article in press: April 20, 2015
Published online: June 18, 2015
Peer-review started: February 9, 2015
First decision: March 20, 2015
Revised: March 31, 2015
Accepted: April 16, 2015
Article in press: April 20, 2015
Published online: June 18, 2015
Core Tip
Core tip: Among different racial and ethnic populations in the United States, Hispanics (predominantly of Mexican origin) are at particular risk for nonalcoholic fatty liver disease (NAFLD) and appear to have a more aggressive disease course. From the risk stratification and early intervention perspective, it is pivotal to define the magnitude of the burden of NAFLD in asymptomatic individuals in Hispanic communities and identify the subset with nonalcoholic steatohepatitis (NASH). Such community based data are scarce. In this study, we assessed the potential burden of NASH and advanced fibrosis in a Hispanic community utilizing four common diagnostic panels and ultrasonography.