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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 8, 2015; 7(10): 1325-1336
Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1325
Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1325
Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosis
Licia Polimeni, Francesco Angelico, Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, Italy
Maria Del Ben, Francesco Baratta, Ludovica Perri, Fabiana Albanese, Daniele Pastori, Francesco Violi, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, Italy
Author contributions: Polimeni L and Del Ben M substantially contributed to conception and design of the review; Polimeni L, Baratta F, Perri L, Albanese F and Pastori D drafted the article and contributed to acquisition and interpretation of data; Violi F and Angelico F contributed to conception of the review and gave final approval of the version of the article to be published.
Conflict-of-interest: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Francesco Angelico, MD, Professor, Department of Public Health and Infectious Diseases, Sapienza University of Rome, 155 viale del Policlinico, 00161 Rome, Italy. francesco.angelico@uniroma1.it
Telephone: +39-6-49972249 Fax: +39-6-49972249
Received: August 14, 2014
Peer-review started: August 15, 2014
First decision: November 27, 2014
Revised: December 1, 2014
Accepted: March 16, 2015
Article in press: March 18, 2015
Published online: June 8, 2015
Peer-review started: August 15, 2014
First decision: November 27, 2014
Revised: December 1, 2014
Accepted: March 16, 2015
Article in press: March 18, 2015
Published online: June 8, 2015
Core Tip
Core tip: Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease, including a wide spectrum of conditions ranging from simple fatty liver to non-alcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma and liver mortality. NAFLD is considered the liver manifestation of the metabolic syndrome. The increased mortality of patients with NAFLD is primarily a result of cardiovascular disease (CVD). Oxidative stress represents a shared pathophysiological disorder between NAFLD and CVD. Several antioxidant treatments have been proposed in patients with NAFLD, with conflicting results, but no trial has evaluated their cardiovascular effects in this setting. Further studies are needed.