Mamun-Al-Mahtab, Akbar SMF, Uddin H, Khan SI, Rahman S. Early termination of immune tolerance state of hepatitis B virus infection explains liver damage. World J Hepatol 2014; 6(8): 621-625 [PMID: 25232455 DOI: 10.4254/wjh.v6.i8.621]
Corresponding Author of This Article
Dr. Mamun-Al-Mahtab, Associate Professor of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh Rd, Dhaka 1000, Bangladesh. firstname.lastname@example.org
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Early termination of immune tolerance state of hepatitis B virus infection explains liver damage
Mamun-Al-Mahtab, Sheikh Mohammad Fazle Akbar, Helal Uddin, Sakirul Islam Khan, Salimur Rahman
Mamun-Al-Mahtab, Salimur Rahman, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000, Bangladesh
Sheikh Mohammad Fazle Akbar, Department of Medical Sciences, Toshiba General Hospital, Tokyo140-0013, Japan
Helal Uddin, Clinical Research Organization, Dhaka 1213, Bangladesh
Sakirul Islam Khan, Department of Anatomy and Embryology, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan
Author contributions: All authors contributed to this paper.
Correspondence to: Dr. Mamun-Al-Mahtab, Associate Professor of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh Rd, Dhaka 1000, Bangladesh. email@example.com
Received: February 22, 2014 Revised: April 24, 2014 Accepted: June 10, 2014 Published online: August 27, 2014
Core tip: Immune tolerance phase usually prevails for up to 20-25 years in subjects with chronic hepatitis B virus (HBV) infection. However, the present study showed that considerable numbers of chronic HBV-infected patients of Bangladesh lost hepatitis B e antigen and developed anti-HBe. Early termination of immune tolerance phase of these young patients was also associated with elevated alanine aminotransferase, hepatic necroinflammation and considerable hepatic fibrosis in some patients. Treatment guidelines are warranted for these patients as there is a paucity of information about their entity.