Castiella A, Zapata E, Lucena MI, Andrade RJ. Drug-induced autoimmune liver disease: A diagnostic dilemma of an increasingly reported disease. World J Hepatol 2014; 6(4): 160-168 [PMID: 24799984 DOI: 10.4254/wjh.v6.i4.160]
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Received: October 26, 2013 Revised: January 9, 2014 Accepted: April 3, 2014 Published online: April 27, 2014
Core tip: Drug-induced autoimmune liver disease (DIAILD) is a poorly defined and under-reported liver disorder, and, probably, a underestimated liver disease. A small number of drug-induced liver injury (DILI) cases exhibit features typical of autoimmune hepatitis (AIH). To differentiate between true AIH triggered by drugs (DI-AIH) and immune mediated DILI still remains a challenge. Patients diagnosed with DIAILD have frequently had a previous episode of hepatotoxicity. We consider that some basic requirements are needed to be considered before supporting a drug as a trigger of AIH and they should be taken into account by authors, reviewers and editors when cases are published and made available to the scientific community.