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Association between inherited monogenic liver disorders and chronic hepatitis C
Linda Piekuse, Madara Kreile, Agnese Zarina, Zane Steinberga, Scientific Laboratory of Molecular Genetics, Riga Stradins University, Riga LV-1007, Latvia
Valentina Sondore, Jazeps Keiss, Latvian Centre of Infectious Diseases, Riga East University Hospital, Riga LV-1006, Latvia
Baiba Lace, Astrida Krumina, Latvian Biomedical Research and Study Centre, Riga LV-1067, Latvia
Author contributions: Krumina A and Keiss J designed the research protocol; Piekuse L and Lace B performed the research; Piekuse L, Kreile M, Zarina A, and Steinberga Z performed the experiments; Sondore V and Piekuse L analyzed the data; and Piekuse L wrote the manuscript.
Supported by The Latvian Council of Science, National Project, Nos. 09.1384 and 10.0010.02
Correspondence to: Linda Piekuse, MD, Scientific Laboratory of Molecular Genetics, Riga Stradins University, No. 16 Dzirciema Street, Riga LV-1007, Latvia. linda.piekuse@rsu.lv
Telephone: +37-1-67061542 Fax: +37-1-67471815
Received: September 23, 2013
Revised: December 16, 2013
Accepted: January 15, 2014
Published online: February 27, 2014
Revised: December 16, 2013
Accepted: January 15, 2014
Published online: February 27, 2014
Core Tip
Core tip: This is the first study to evaluate the association between hepatitis C and the most frequently inherited monogenic liver diseases (hereditary hemochromatosis, alpha-1 antitrypsin deficiency, Gilbert’s syndrome, and Wilson’s disease) and their causative mutations. This case-control study revealed an association between hepatitis C and the mutation that causes Wilson’s disease. In addition, biochemical data analysis revealed an association between hepatitis C and the mutation that causes Gilbert’s syndrome.