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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 27, 2014; 6(10): 688-695
Published online Oct 27, 2014. doi: 10.4254/wjh.v6.i10.688
Published online Oct 27, 2014. doi: 10.4254/wjh.v6.i10.688
Severe alcoholic hepatitis-current concepts, diagnosis and treatment options
Won Kim, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul 156-707, South Korea
Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea
Author contributions: Kim W collected data, reviewed literatures, and wrote the manuscript; Kim DJ designed this review, appraised critically and revised the manuscript.
Correspondence to: Dong Joon Kim, MD, PhD, Professor, Department of Internal Medicine, Hallym University College of Medicine, #153 Gyo-dong, Chuncheon-si, Gangwon-do, Chuncheon 200-704, South Korea. djkim@hallym.ac.kr
Telephone: +82-33-2405646 Fax: +82-33-2418064
Received: August 22, 2014
Revised: September 2, 2014
Accepted: September 16, 2014
Published online: October 27, 2014
Revised: September 2, 2014
Accepted: September 16, 2014
Published online: October 27, 2014
Core Tip
Core tip: We should further explore novel molecular targets to restore altered gut mucosal integrity, suppress inflammation based on cytokine profiles, promote hepatic regeneration, and limit innate immune responses in severe alcoholic steatohepatitis.