Verduci E, Pozzato C, Banderali G, Radaelli G, Arrizza C, Rovere A, Riva E, Giovannini M. Changes of liver fat content and transaminases in obese children after 12-mo nutritional intervention. World J Hepatol 2013; 5(9): 505-512 [PMID: 24073302 DOI: 10.4254/wjh.v5.i9.505]
Corresponding Author of This Article
Elvira Verduci, PhD, Department of Pediatrics, San Paolo Hospital, University of Milan, Via A Di Rudinì 8, 20142 Milan, Italy. email@example.com
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Changes of liver fat content and transaminases in obese children after 12-mo nutritional intervention
Elvira Verduci, Carlo Pozzato, Giuseppe Banderali, Giovanni Radaelli, Chiara Arrizza, Antonio Rovere, Enrica Riva, Marcello Giovannini
Elvira Verduci, Giuseppe Banderali, Giovanni Radaelli, Chiara Arrizza, Enrica Riva, Marcello Giovannini, Department of Pediatrics, San Paolo Hospital, University of Milan, 20142 Milan, Italy
Carlo Pozzato, Antonio Rovere, Department of Radiology, San Paolo Hospital, 20142 Milan, Italy
Giovanni Radaelli, Unit of Medical Statistics, San Paolo Hospital, University of Milan, 20142 Milan, Italy
Author contributions: Verduci E, Pozzato C, Banderali G, Arrizza C and Rovere A contributed to direct participation in the study, including substantial contributions to conception and design of study, or acquisition of data, or analysis and interpretation of data, or supportive contributions; Verduci E, Pozzato C, Riva E and Giovannini M contributed to manuscript writing, including drafting the article, or revising it critically for intellectual content; Radaelli G contributed to supportive work, including statistical analysis of data and interpretation.
Correspondence to: Elvira Verduci, PhD, Department of Pediatrics, San Paolo Hospital, University of Milan, Via A Di Rudinì 8, 20142 Milan, Italy. firstname.lastname@example.org
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Received: May 1, 2013 Revised: August 2, 2013 Accepted: August 16, 2013 Published online: September 27, 2013
Core tip: In our study we demonstrate that in obese children longitudinal change in liver fat content evaluated on magnetic resonance imaging is associated with change in serum transaminases and more weakly also with changes in triglyceridemia and apolipoproteins, after a nutritional intervention based on normocaloric balanced diet. Furthemore this is the first study purposely designed to evaluate in obese children whether any relationship may exist of longitudinal changes in liver fat content with changes in liver biochemical parameters These findings may suggest novelty in clinical monitoring nonalcoholic fatty liver disease severity in childhood obesity.