Neurologic complications after liver transplantation

Core Tip

Core tip: Neurologic complications after liver transplantation are still a major source of morbidity and mortality and careful approach to possible immunosuppressant neurotoxicity and opportunistic infections is needed. Most common neurologic complications include encephalopathy, seizures and cerebrovascular complications, but opportunistic central nervous system infections and central pontine myelinolysis may be associated with significant morbidity as well. Accurate diagnosis and timely intervention are essential to improve outcomes, while advances in clinical management of neurologic post-transplant complications and extended post-transplant survival are increasingly shifting the focus to chronic post-transplant complications which are often encountered in a community hospital and an outpatient setting.