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World J Hepatol. Jul 27, 2013; 5(7): 379-386
Published online Jul 27, 2013. doi: 10.4254/wjh.v5.i7.379
Published online Jul 27, 2013. doi: 10.4254/wjh.v5.i7.379
Effect of dichloromethylene diphosphonate on liver regeneration following thioacetamide-induced necrosis in rats
Mirandeli Bautista, Ana María Téllez-López, Maricela López-Orozco, Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, CP 42000, México
María Ángeles Gómez del Rio, Juana Benedí, Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Ciudad Universitaria, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain
María Isabel Sánchez-Reus, Departamento de Farmacología, Facultad de Farmacia, Ciudad Universitaria, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain
José A Morales-González, Escuela Superior de Medicina, Instituto Politécnico Nacional, México City, CP 11340, México
Author contributions: All authors contributed equally to conducting the research and writing the paper.
Correspondence to: Dr. Mirandeli Bautista, Área Académica de Farmacia, Instituto de Ciencias de la Salud,Universidad Autónoma del Estado de Hidalgo, Abasolo N. 600, Colonia Centro, Pachuca, Hidalgo, CP 42000, México. mirandeli@hotmail.com
Telephone: +7-71-7172000 Fax: +7-71-7172000
Received: March 30, 2013
Revised: June 17, 2013
Accepted: June 18, 2013
Published online: July 27, 2013
Processing time: 117 Days and 2 Hours
Revised: June 17, 2013
Accepted: June 18, 2013
Published online: July 27, 2013
Processing time: 117 Days and 2 Hours
Core Tip
Core tip: Over the last 20 years, liposomes, useful models for cell membranes, have become a powerful research tool whose study has resulted in many advances in cell physiology. When encapsulated in liposomes, dichloromethylene diphosphonate, a selective Kupffer cell toxicant, completely eliminates large Kupffer cells from the liver, allowing us to elucidate the role of these macrophages in total damage induced by hepatotoxic compounds such as thioacetamide.