Alam S, Noor-E-Alam SM, Chowdhury ZR, Alam M, Kabir J. Nonalcoholic steatohepatitis in nonalcoholic fatty liver disease patients of Bangladesh. World J Hepatol 2013; 5(5): 281-287 [PMID: 23717739 DOI: 10.4254/wjh.v5.i5.281]
Corresponding Author of This Article
Shahinul Alam, Associate Professor, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, BSMMU, Shahbag, Dhaka 1000, Bangladesh. shahinul67@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Shahinul Alam, Sheikh Mohammad Noor-E-Alam, Ziaur Rahman Chowdhury, Mahabubul Alam, Jahangir Kabir, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh
Author contributions: Alam S contributed to the conception and design of the research; Noor-E-Alam SM contributed to the design of the research and to the data collection; Chowdhury ZR contributed to the data analysis and interpretation; Alam M contributed toward drafting the manuscript; and Kabir J critically revised the paper.
Correspondence to: Shahinul Alam, Associate Professor, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, BSMMU, Shahbag, Dhaka 1000, Bangladesh. shahinul67@yahoo.com
Telephone: +88-2-8610779 Fax: +88-2-8122917
Received: February 17, 2013 Revised: April 30, 2013 Accepted: May 8, 2013 Published online: May 27, 2013 Processing time: 99 Days and 0.7 Hours
Core Tip
Core tip: We have designed this study to explore the prevalence of and risk factors for nonalcoholic steatohepatitis (NASH) in nonalcoholic fatty liver disease patients. Other causes of liver disease were excluded. A total of 493 patients with sonographic evidence of fatty change were considered, and 177 of these patients were evaluated and confirmed by liver biopsy after making exclusions. Females were predominant (250, 57.0%). Central obesity was more prevalent among the patients compared with overall obesity. NASH was observed in 75 (42.4%) of the cases. The presence of diabetes and elevated gamma-glutamyl transpeptidase could differentiate NASH from simple steatosis. Serum alanine aminotransferase and aspartate aminotransferase could not be used to detect NASH.
