Brief Article
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World J Hepatol. May 27, 2013; 5(5): 281-287
Published online May 27, 2013. doi: 10.4254/wjh.v5.i5.281
Nonalcoholic steatohepatitis in nonalcoholic fatty liver disease patients of Bangladesh
Shahinul Alam, Sheikh Mohammad Noor-E-Alam, Ziaur Rahman Chowdhury, Mahabubul Alam, Jahangir Kabir
Shahinul Alam, Sheikh Mohammad Noor-E-Alam, Ziaur Rahman Chowdhury, Mahabubul Alam, Jahangir Kabir, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh
Author contributions: Alam S contributed to the conception and design of the research; Noor-E-Alam SM contributed to the design of the research and to the data collection; Chowdhury ZR contributed to the data analysis and interpretation; Alam M contributed toward drafting the manuscript; and Kabir J critically revised the paper.
Correspondence to: Shahinul Alam, Associate Professor, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, BSMMU, Shahbag, Dhaka 1000, Bangladesh. shahinul67@yahoo.com
Telephone: +88-2-8610779 Fax: +88-2-8122917
Received: February 17, 2013
Revised: April 30, 2013
Accepted: May 8, 2013
Published online: May 27, 2013
Processing time: 99 Days and 0.7 Hours
Core Tip

Core tip: We have designed this study to explore the prevalence of and risk factors for nonalcoholic steatohepatitis (NASH) in nonalcoholic fatty liver disease patients. Other causes of liver disease were excluded. A total of 493 patients with sonographic evidence of fatty change were considered, and 177 of these patients were evaluated and confirmed by liver biopsy after making exclusions. Females were predominant (250, 57.0%). Central obesity was more prevalent among the patients compared with overall obesity. NASH was observed in 75 (42.4%) of the cases. The presence of diabetes and elevated gamma-glutamyl transpeptidase could differentiate NASH from simple steatosis. Serum alanine aminotransferase and aspartate aminotransferase could not be used to detect NASH.