Licata A, Maida M, Bonaccorso A, Macaluso FS, Cappello M, Craxì A, Almasio PL. Clinical course and prognostic factors of hepatorenal syndrome: A retrospective single-center cohort study. World J Hepatol 2013; 5(12): 685-691 [PMID: 24432185 DOI: 10.4254/wjh.v5.i12.685]
Corresponding Author of This Article
Piero Luigi Almasio, MD, Section of Gastroenterology, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Piazza delle Cliniche, 290127 Palermo, Italy. piero.almasio@unipa.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
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World J Hepatol. Dec 27, 2013; 5(12): 685-691 Published online Dec 27, 2013. doi: 10.4254/wjh.v5.i12.685
Clinical course and prognostic factors of hepatorenal syndrome: A retrospective single-center cohort study
Anna Licata, Marcello Maida, Ambra Bonaccorso, Fabio Salvatore Macaluso, Maria Cappello, Antonio Craxì, Piero Luigi Almasio
Anna Licata, Marcello Maida, Ambra Bonaccorso, Fabio Salvatore Macaluso, Maria Cappello, Antonio Craxì, Piero Luigi Almasio, Section of Gastroenterology, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, 290127 Palermo, Italy
Author contributions: Licata A, Maida M and Almasio PL designed the study, they were responsible for the drafting of the manuscript, and they participated in the statistical analysis and data collection; Bonaccorso A, Macaluso FS and Cappello M participated in the data collection and drafting of the manuscript; Craxì A and Almasio PL were responsible for the project and the drafting of the manuscript; all of the authors have seen and approved the final version of the manuscript.
Correspondence to: Piero Luigi Almasio, MD, Section of Gastroenterology, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Piazza delle Cliniche, 290127 Palermo, Italy. piero.almasio@unipa.it
Telephone: +39-91-6553131 Fax: +39-91-6552223
Received: September 2, 2013 Revised: September 26, 2013 Accepted: November 15, 2013 Published online: December 27, 2013 Processing time: 130 Days and 22.3 Hours
Core Tip
Core tip: Hepatorenal syndrome (HRS) is a life-threatening complication of advanced liver disease. The aims of this study were to investigate the clinical and biochemical features of HRS, to assess short- and long-term survival, and to evaluate the presence of potential predictors of early mortality. Thirty-three patients with liver cirrhosis and HRS were retrospectively reviewed. Median survival was 30 d. By univariate analysis Child-Pugh class C, hepatocellular carcinoma, low serum sodium, high bilirubin and high Model for End-stage Liver Disease (MELD) score were predictive factors of 30-d mortality. By multivariate analysis, only serum sodium < 132 mEq/L and MELD score > 27 were independently associated with survival of less than one month.
