Chiu KW, Nakano T, Chen KD, Hsu LW, Lai CY, Chiu HC, Huang CY, Cheng YF, Goto S, Chen CL. Homogeneous phenomenon of the graft when using different genotype characteristic of recipients/donors in living donor liver transplantation. World J Hepatol 2013; 5(11): 642-648 [PMID: 24303093 DOI: 10.4254/wjh.v5.i11.642]
Corresponding Author of This Article
Chao-Long Chen, MD, Liver Transplant Program, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan. firstname.lastname@example.org
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Author contributions: Chiu KW and Chen CL designed research; Nakano T and Chen KD performed research; Hsu LW, Lai CY, Chiu HC and Huang CY contributed new reagents or analytic tools; Cheng YF and Goto S analyzed data; Chiu KW and Nakano T wrote the paper.
Supported by A grant from Chang Gung Memorial Hospital, CMRPG8A0631 to Chiu KW of Taiwan
Correspondence to: Chao-Long Chen, MD, Liver Transplant Program, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan. email@example.com
Telephone: +886-7-7317123 Fax: +886-7-7336856
Received: August 11, 2013 Revised: September 28, 2013 Accepted: October 17, 2013 Published online: November 27, 2013
Core tip: The most innovative concept is that pyrosequencing can deeply clarify the proportional change of the A and G alleles in CYP3A5*3, C and T alleles in MDR1-3435, and T and C alleles in CYP3A4*1 when the different genotype of single nucleotide polymorphism after living donor liver transplantation. The biogenetic characteristic of the recipient could be modified by a donor you want to change the genetic characteristic. For further confirmation, homogeneous phenomenon was the truly occurred in the cytochrome P450 system when the recipients and donors with different genotype of the single nucleotide polymorphism.