Homogeneous phenomenon of the graft when using different genotype characteristic of recipients/donors in living donor liver transplantation

doi:10.4254/wjh.v5.i11.642

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Nov 27, 2013 (publication date) through May 2, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2013; 5(11): 642-648
Published online Nov 27, 2013. doi: 10.4254/wjh.v5.i11.642

Homogeneous phenomenon of the graft when using different genotype characteristic of recipients/donors in living donor liver transplantation

King-Wah Chiu, Toshiaki Nakano, Kuang-Den Chen, Li-Wen Hsu, Chia-Yun Lai, Ho-Ching Chiu, Ching-Yin Huang, Yu-Fan Cheng, Shigeru Goto, Chao-Long Chen

King-Wah Chiu, Toshiaki Nakano, Kuang-Den Chen, Li-Wen Hsu, Chia-Yun Lai, Ho-Ching Chiu, Ching-Yin Huang, Yu-Fan Cheng, Shigeru Goto, Chao-Long Chen, Liver Transplant Program, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung 833, Taiwan

Author contributions: Chiu KW and Chen CL designed research; Nakano T and Chen KD performed research; Hsu LW, Lai CY, Chiu HC and Huang CY contributed new reagents or analytic tools; Cheng YF and Goto S analyzed data; Chiu KW and Nakano T wrote the paper.

Supported by A grant from Chang Gung Memorial Hospital, CMRPG8A0631 to Chiu KW of Taiwan

Correspondence to: Chao-Long Chen, MD, Liver Transplant Program, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan. chchen@adm.cgmh.org.tw

Telephone: +886-7-7317123 Fax: +886-7-7336856

Received: August 11, 2013
Revised: September 28, 2013
Accepted: October 17, 2013
Published online: November 27, 2013

Core Tip

Core tip: The most innovative concept is that pyrosequencing can deeply clarify the proportional change of the A and G alleles in CYP3A5*3, C and T alleles in MDR1-3435, and T and C alleles in CYP3A4*1 when the different genotype of single nucleotide polymorphism after living donor liver transplantation. The biogenetic characteristic of the recipient could be modified by a donor you want to change the genetic characteristic. For further confirmation, homogeneous phenomenon was the truly occurred in the cytochrome P450 system when the recipients and donors with different genotype of the single nucleotide polymorphism.