This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Matching donor to recipient in liver transplantation: Relevance in clinical practice
Mettu Srinivas Reddy, Joy Varghese, Jayanthi Venkataraman, Mohamed Rela
Mettu Srinivas Reddy, Mohamed Rela, Institute of Liver Diseases and Transplantation, Global Hospital and Health City, Chennai 600100, India
Joy Varghese, Jayanthi Venkataraman, Department of Hepatology and Transplantation, Institute of Liver Diseases and Transplantation, Global Hospital and Health City, Chennai 600100, India
Author contributions: All authors contributed to the manuscript.
Correspondence to: Mettu Srinivas Reddy, PhD, Institute of Liver Diseases and Transplantation, Global Hospital and Health City, 439 Cheran Nagar Perumbakkam, Chennai 600100, India. email@example.com
Telephone: +91-44-2777000 Fax: +91-44-2777100
Received: October 15, 2013 Revised: October 23, 2013 Accepted: November 2, 2013 Published online: November 27, 2013
Core tip: Multiple donor and recipient factors impact graft survival after liver transplantation. In addition, interaction between donor, graft and recipient factors may significantly affect management and outcomes. Appropriate matching based on donor-organ-recipient variables can avoid wastage of liver grafts, improve outcomes and decrease graft loss. Modification of surgical techniques and innovative peri-transplant strategies can expand the donor pool by utilizing grafts from marginal donors that are traditionally turned down.