Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2025; 17(8): 108474
Published online Aug 27, 2025. doi: 10.4254/wjh.v17.i8.108474
Iron metabolism and sepsis-associated liver injury: Methodological considerations and clinical perspectives
Gokhan Koker
Gokhan Koker, Department of Internal Medicine, University of Health and Sciences Antalya Training and Research Hospital, Antalya 07050, Türkiye
Author contributions: Koker G was solely responsible for the conception, design, writing, and critical revision of the manuscript.
Conflict-of-interest statement: The author has no conflicts of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gokhan Koker, MD, Assistant Professor, Department of Internal Medicine, University of Health and Sciences Antalya Training and Research Hospital, Varlık mah, Antalya 07050, Türkiye. gkhnkkr@gmail.com
Received: April 15, 2025
Revised: May 9, 2025
Accepted: July 2, 2025
Published online: August 27, 2025
Processing time: 134 Days and 10.6 Hours
Core Tip

Core Tip: This letter to the editor provided commentary on a recent study addressing the relationship between iron metabolism and sepsis-associated liver injury. Key methodological considerations, including the absence of hepcidin (a central iron-regulating hormone) in the biomarker panel, and the reliance solely on biochemical criteria for sepsis-associated liver injury diagnosis were highlighted. The importance of serial measurements and imaging-based confirmation was emphasized. The discussion aimed to enhance clinical interpretation and guide future studies on the prognostic role of iron-related markers in critical care settings.