Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2025; 17(8): 108063
Published online Aug 27, 2025. doi: 10.4254/wjh.v17.i8.108063
Sex differences in severity, outcomes, and healthcare utilization in alcohol-associated hepatitis
Elizabeth Harris, Christian Rhudy, Lucas Roy, Amber Cloud, Christina Delacruz Leyson
Elizabeth Harris, Department of Gastroenterology and Hepatology, Marshall University, Huntington, WV 25701, United States
Christian Rhudy, College of Pharmacy, University of Kentucky, Lexington, KY 40508, United States
Lucas Roy, Amber Cloud, Internal Medicine Residency Program, University of Kentucky, Lexington, KY 40508, United States
Christina Delacruz Leyson, Division of Digestive Diseases and Nutrition, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY 40536, United States
Author contributions: Leyson CD, Roy L conceptualized and designed the research study and obtained data; Harris E, Rhudy C, performed initial data analysis; Cloud A, Roy L performed chart review; Rhudy C performed statistical analysis; Harris E wrote the manuscript. All authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the University of Kentucky Institutional Review Board (Approval No. 63653).
Informed consent statement: This was a retrospective chart review with no identifiable patient information presented. The patient was exempt from informed consent.
Conflict-of-interest statement: None of the authors have any financial, professional, or personal disclosures.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at (harrise@marshall.edu). Consent was not obtained but the presented data are anonymized and risk of identification is low.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Elizabeth Harris, MD, Department of Gastroenterology and Hepatology, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, United States. lizzy4910@gmail.com
Received: April 10, 2025
Revised: May 26, 2025
Accepted: July 9, 2025
Published online: August 27, 2025
Processing time: 139 Days and 16.7 Hours
Core Tip

Core Tip: Females with alcohol-associated hepatitis had higher incidence of urinary tract infection, sepsis, and norepinephrine administration on univariate analysis. On multivariate logistic regression analysis, females had higher odds of sepsis and mechanical ventilation, which were both found to be independent predictors of mortality.